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Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
Published on: April 27, 2014
A nationwide population-based study on bladder pain syndrome/interstitial cystitis and ED
11] Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Taipei, Taiwan [2] Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan [3] School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.
International Journal of Impotence Research
|April 5, 2013
Summary
Bladder pain syndrome/interstitial cystitis (BPS/IC) is linked to erectile dysfunction (ED). This population study found BPS/IC was more common in ED patients, especially younger men, suggesting a potential association.
Area of Science:
- Urology
- Andrology
- Inflammation Research
Background:
- Bladder pain syndrome/interstitial cystitis (BPS/IC) involves inflammatory pathways that can lead to endothelial dysfunction.
- Endothelial dysfunction is a significant risk factor for the development of erectile dysfunction (ED).
Purpose of the Study:
- To investigate the potential association between BPS/IC and ED.
- To analyze the prevalence of prior BPS/IC diagnosis in ED patients compared to controls.
Main Methods:
- A population-based case-control study using Taiwan's National Health Insurance Research Database.
- Included 32,856 ED patients (cases) and 164,280 matched controls (≥18 years old).
- Conditional logistic regression analysis was used to compare the odds of prior BPS/IC diagnosis between cases and controls, adjusting for covariates.
Main Results:
- The overall prevalence of prior BPS/IC was 0.05%.
- ED cases showed a significantly higher prevalence of prior BPS/IC (0.10%) compared to controls (0.04%) (P<0.001).
- An adjusted odds ratio of 1.75 (95% CI=1.12-2.71) indicated an association between BPS/IC and ED. The association was strongest in the youngest age group (18-39 years, OR=10.40).
Conclusions:
- This study demonstrates a significant association between BPS/IC and ED.
- Younger men with ED exhibited the strongest association with a prior BPS/IC diagnosis.
- The findings suggest that inflammatory processes in BPS/IC may contribute to ED development.
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