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Updated: May 12, 2026
06:35
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Antacid-induced acute pancreatitis.
1Mercer University College of Health Science, Atlanta, Georgia St. Joseph's Hospital, Atlanta, GA 30041, USA. Nykamp_D@mercer.edu
Summary
High doses of over-the-counter (OTC) calcium carbonate antacids can lead to severe hypercalcemia and acute pancreatitis. Patients should adhere to recommended dosages to prevent serious adverse events.
Area of Science:
- Gastroenterology
- Internal Medicine
- Clinical Case Reports
Background:
- Over-the-counter (OTC) antacids containing calcium carbonate are widely used for managing acid reflux.
- Excessive intake of calcium carbonate can lead to hypercalcemia, a condition of abnormally high calcium levels in the blood.
Observation:
- A 68-year-old male presented with severe nausea, vomiting, and abdominal pain.
- The patient reported consuming 15-20 calcium carbonate antacid tablets daily for several days prior to admission.
- Upon admission, the patient exhibited markedly elevated serum calcium (18.5 mg/dL), amylase (2,768 U/L), and lipase (7,091 U/L) levels.
Findings:
- Abdominal computed tomography confirmed the diagnosis of acute pancreatitis.
- The patient required intensive care for 45 days, including treatment for necrotizing pancreatitis.
- The clinical presentation and laboratory findings strongly suggest a causal link between excessive calcium antacid intake and acute pancreatitis.
Implications:
- This case highlights the potential for serious adverse events, including acute pancreatitis, from the overuse of OTC calcium carbonate antacids.
- Healthcare providers should counsel patients on the risks associated with exceeding recommended dosages of calcium-containing antacids.
- Awareness of this association is crucial for timely diagnosis and management of pancreatitis in patients with a history of high antacid consumption.
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10:39Preparation of Pancreatic Acinar Cells for the Purpose of Calcium Imaging, Cell Injury Measurements, and Adenoviral Infection
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