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Updated: May 12, 2026
10:33
Detecting Migration and Infiltration of Neutrophils in Mice
Published on: February 6, 2020
Neutrophils in innate and adaptive immunity
Sébastien Jaillon1, Maria Rosaria Galdiero, Davide Del Prete
1Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano, Milan, Italy.
Seminars in Immunopathology
|April 5, 2013
Summary
Neutrophils are key immune cells that do more than fight pathogens. Emerging research shows they regulate immune responses and influence diseases like cancer and autoimmunity.
Area of Science:
- Immunology
- Cell Biology
Background:
- Neutrophils were traditionally considered short-lived cells primarily for pathogen elimination.
- Their role in orchestrating immune responses was thought to be limited.
Purpose of the Study:
- To challenge the traditional view of neutrophils.
- To highlight their broader functions in immune regulation and disease.
Main Methods:
- Review of recent scientific literature.
- Analysis of evidence on neutrophil-derived cytokines and effector molecules.
- Examination of neutrophil polarization and interactions with other immune cells.
Main Results:
- Neutrophils express numerous cytokines and effector molecules.
- They can be polarized into anti-tumoral or pro-tumoral phenotypes.
- Neutrophils contribute to humoral innate immunity and shape other leukocytes' functions.
- They play a role in both resolution and exacerbation of various pathologies.
Conclusions:
- Neutrophils are integral to both innate and adaptive immunity.
- They significantly influence diverse pathologies, including infections, inflammation, autoimmunity, and cancer.
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