Gender differences in long-term outcome after primary percutaneous intervention for ST-segment elevation myocardial...

Area of Science:

• Cardiology
• Interventional Cardiology
• Clinical Outcomes

Background:

• Previous studies on gender differences in ST-segment elevation myocardial infarction (STEMI) outcomes are outdated, predating current percutaneous coronary intervention (PCI) techniques and therapies.
• This study assesses gender-based long-term outcomes in STEMI patients treated with primary PCI.

Purpose of the Study:

• To evaluate the influence of gender on long-term outcomes in STEMI patients.
• To compare major adverse cardiac events (MACE) and mortality rates between women and men after primary PCI.

Main Methods:

• Utilized two-year follow-up data from the DEBATER trial, including 202 women and 668 men with STEMI who underwent primary PCI.
• Defined the primary endpoint as MACE (composite of death, myocardial infarction, target vessel revascularization).

Main Results:

• Women were older and had higher rates of diabetes and hypertension compared to men.
• At two years, women exhibited significantly higher MACE (21% vs. 14%) and mortality (8% vs. 2.6%) rates.
• Multivariate analysis, adjusted for age and baseline characteristics, revealed similar MACE and mortality rates between genders.

Conclusions:

• Higher MACE and mortality rates in women post-primary PCI for STEMI are attributed to older age and elevated baseline risk profiles.
• After adjusting for confounding factors, long-term outcomes are comparable between men and women following primary PCI for STEMI.