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Gavage Strategy for Decoction Formula of Traditional Chinese Medicine in Osteosarcoma Model Mice

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Animal studies on medicinal herbs: predictability, dose conversion and potential value.

Ken Wojcikowski¹, Glenda Gobe

¹School of Health and Human Sciences, Southern Cross University, Lismore, NSW, Australia.

Phytotherapy Research : PTR

|April 5, 2013

Summary

Translational researchers and clinicians often misinterpret medicinal herb studies. Using allometric scaling, not milligram per kilogram dosing, is crucial for accurate human dose equivalents and therapeutic value assessment.

Keywords:

allometric scaling conversion correlation dose translation equivalent medicinal herbs

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Area of Science:

Pharmacology
Toxicology
Herbal Medicine Research

Background:

Animal studies on medicinal herbs are frequently misinterpreted.
Lack of standardized methods for dose conversion leads to inaccurate extrapolation.
Common errors involve using milligram per kilogram (mg/kg) basis for interspecies scaling.

Purpose of the Study:

To highlight the misinterpretation of animal studies on medicinal herbs.
To emphasize the importance of appropriate methods for human dose extrapolation.
To advocate for the use of allometric scaling in translating animal study results.

Main Methods:

Critique of the milligram per kilogram (mg/kg) method for dose conversion.
Introduction and recommendation of allometric scaling based on body surface area (BSA).
Discussion of pharmacokinetic and pharmacodynamic differences between species.

Main Results:

The mg/kg method can lead to underestimation of toxicity or overestimation of therapeutic dosage.
Allometric scaling offers a more reliable approach for interspecies dose translation.
Despite inherent interspecies variability, correct scaling improves predictability.

Conclusions:

Accurate interpretation of animal studies is vital for translational research and clinical application of medicinal herbs.
Allometric scaling should be the standard method for converting animal doses to human equivalents.
Well-designed animal studies, when correctly interpreted, provide unique insights beyond in vitro or computational methods.