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The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
Published on: October 7, 2016
New hydrogel obtained from a novel dendritic monomer as a promising candidate for biomedical applications
Julio César Cuggino1, Germán Charles, Gerardo Gatti
1Departamento de Química Orgánica, IMBIV-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina.
Abstract:
Acid functional hydrogels are a type of materials with many advantages. Over the last years, increasing attention for the synthesis of dendronized polymers has been drawn due to their unique properties of high multivalence in the same surface as compared with conventional polymers. In this study, we report the preparation of novel acid dendronized hydrogels using a dendritic monomer obtained from Behera's amine. The swelling and rheological performance, the non-toxicity over fibroblast cells and the drug encapsulation capacity of the novel hydrogels suggests that the new materials can achieve great potential as carrier for drug delivery and other potential biomedical applications.
