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Spanish LupusPRO: cross-cultural validation study for lupus
1Dept. of Medicine, Rush University Medical Center, Chicago, Il 60612, USA. Meenakshi_Jolly@rush.edu
Lupus
|April 5, 2013
Summary
The Spanish LupusPRO tool demonstrates good reliability and validity for assessing systemic lupus erythematosus (SLE) in Spanish-speaking patients. This validated patient-reported outcome measure is now ready for clinical trials.
Area of Science:
- Rheumatology
- Patient-Reported Outcomes
- Psychometrics
Background:
- The LupusPRO is a validated patient-reported outcome measure for systemic lupus erythematosus (SLE) in the US.
- Cross-cultural adaptation is essential to expand the utility of health outcome measures.
Purpose of the Study:
- To cross-culturally adapt and validate the Spanish version of the LupusPRO.
- To assess the psychometric properties of the Spanish LupusPRO in SLE patients.
Main Methods:
- Forward-back translation and pretesting of the English LupusPRO.
- Administration of the Spanish LupusPRO and SF-36 to 211 Spanish-speaking SLE patients.
- Evaluation of internal consistency, test-retest reliability, criterion validity, and convergent validity.
Main Results:
- The Spanish LupusPRO demonstrated good test-retest reliability (0.80-0.95) and internal consistency (0.71-0.96).
- Criterion validity was established through good performance against disease activity measures.
- Convergent validity was confirmed with the SF-36, and confirmatory factor analysis showed a good fit.
Conclusions:
- The Spanish LupusPRO possesses adequate psychometric properties for use in clinical research.
- This validated Spanish tool is now available for clinical trials and longitudinal studies evaluating responsiveness to change in SLE patients.
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