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Related Concept Videos

Adhesion01:14

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
Types of Membrane Protrusions01:28

Types of Membrane Protrusions

The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections with a...
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...

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Related Experiment Video

Updated: May 12, 2026

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface
13:22

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface

Published on: November 2, 2011

Preload-responsive adhesion: effects of aspect ratio, tip shape and alignment.

Dadhichi Paretkar1, Marleen Kamperman, David Martina

  • 1INM-Leibniz Institute for New Materials, Functional Surfaces Group, Saarland University, Saarbruecken, Germany. dadhichi.paretkar@inm-gmbh.de

Journal of the Royal Society, Interface
|April 5, 2013
PubMed
Summary
This summary is machine-generated.

We investigated how polymer fibril shape and preload affect adhesion. Round-edged fibrils lose adhesion upon buckling, while end-flapped fibrils maintain adhesion until very high preloads.

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Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay

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Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation
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Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation

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Last Updated: May 12, 2026

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface
13:22

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface

Published on: November 2, 2011

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay
08:24

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay

Published on: September 27, 2021

Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation
14:46

Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation

Published on: January 20, 2018

Area of Science:

  • Biomimetics and surface science
  • Adhesion science and nanotechnology

Background:

  • Bio-inspired adhesives often mimic natural structures like gecko or beetle feet.
  • Controlling adhesion at the microscale is crucial for applications in robotics and smart materials.

Purpose of the Study:

  • To investigate the adhesive response of polymer surfaces with structured micro-fibrils.
  • To understand the role of fibril tip shape and preload on adhesion switching.

Main Methods:

  • Fabrication of polymer surfaces with cylindrical fibrils (10-20 µm diameter, aspect ratio 1-2.4).
  • Utilized preload-induced mechanical buckling instability to control adhesion states.
  • In situ observation of fibril behavior and contact recovery.

Main Results:

  • Round-edged fibrils lost adhesion upon buckling at moderate preloads.
  • End-flapped fibrils retained adhesion after buckling reversal until very high preloads.
  • Fibril-probe alignment influenced the adhesion loss preload for end-flapped structures.

Conclusions:

  • Fibril tip geometry significantly impacts adhesion switching capabilities.
  • Mechanical buckling instability combined with specific tip designs offers tunable adhesion control.
  • These findings can inform the design of switchable bio-inspired adhesive systems.