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[Toxicity of cis-platinum loaded with lactic acid oligomer microspheres in mice]
T Sasabe1, T Takahashi, A Hagiwara
11st Dept. of Surgery, Kyoto Prefectural Univ.
Gan No Rinsho. Japan Journal of Cancer Clinics
|June 1, 1990
Abstract:
We have evaluated the acute toxicity of an experimental new dosage form administered intraperitoneally in mice, consisting of cis-platinum loaded with lactic acid oligomer microspheres (CDDP-ms). The LD50 value of the CDDP-ms was 23.8 mg/kg, which amounted to 176% of the LD50 of the cis-platinum solution (13.5 mg/kg). Autopsy findings revealed no additional toxicity due to this dosage form.