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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

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Related Experiment Video

Updated: May 12, 2026

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
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PET imaging for receptor occupancy: meditations on calculation and simplification.

Yumin Zhang1, Gerard B Fox

  • 1Translational Sciences, Global Pharmaceutical R & D, Abbott Laboratories, Abbott Park, IL 60064, USA.

Journal of Biomedical Research
|April 5, 2013
PubMed
Summary

This review simplifies measuring receptor occupancy using positron emission tomography (PET) imaging. It offers practical guidance and mathematical explanations for developing central nervous system drugs.

Keywords:
central nervous systemdrug developmentpositron emission tomographyreceptor imagingreceptor occupancy

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Area of Science:

  • Neuroscience
  • Radiochemistry
  • Pharmacology

Background:

  • Positron emission tomography (PET) is crucial for in vivo imaging.
  • Accurate receptor occupancy measurement is vital for drug development.
  • Challenges exist in standardizing PET imaging protocols.

Purpose of the Study:

  • To provide a pragmatic approach to positron emission tomography imaging for receptor occupancy.
  • To elucidate the mathematics of receptor occupancy calculations.
  • To offer insights for developing drugs targeting central nervous system receptors.

Main Methods:

  • Review of established procedures for receptor occupancy measurement.
  • Systematic explanation of receptor occupancy calculation mathematics.
  • Discussion of practical considerations and challenges in PET imaging.

Main Results:

  • A simplified, pragmatic methodology for PET receptor occupancy studies.
  • Clear mathematical frameworks for receptor occupancy calculations.
  • Insights into optimizing PET imaging for drug development.

Conclusions:

  • Positron emission tomography offers a valuable tool for measuring receptor occupancy.
  • Practical guidance and clear mathematical understanding can facilitate drug development.
  • This approach aids in targeting central nervous system receptors effectively.