Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...

Blood Pressure Imbalances and Circulatory Shock

Blood Pressure Imbalances and Circulatory Shock

Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...

Male Sexual Response: Erection & Ejaculation

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...

Electroconvulsive Therapy

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...

Shock Waves

Shock Waves

While deriving the Doppler formula for the observed frequency of a sound wave, it is assumed that the speed of sound in the medium is greater than the source's speed through it. When this condition is breached, a shock wave occurs.
When the source's speed approaches the speed of sound, constructive interference between successive wavefronts emitted by the source occurs immediately behind it. Initially, scientists believed that this constructive interference would result in such high pressures...

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

What are the mechanisms that enable Radio-Frequency therapy to be effective in managing Erectile Dysfunction? A narrative review.

International journal of impotence research·2026

Same author

Increased prevalence of metabolic syndrome in female patients with overactive bladder: A population-based study.

Neurourology and urodynamics·2024

Same author

New technologies developed for treatment of premature ejaculation.

International journal of impotence research·2024

Same author

Prevalence of the use of oral nutritional supplements among acute inpatients at risk of malnutrition and associated patient characteristics.

Journal of clinical nursing·2024

Same author

Summary Paper of the Updated 2023 European Association of Urology Guidelines on Urological Trauma.

European urology focus·2023

Same author

Long-term effects of combination treatment comprising low-intensity extracorporeal shockwave therapy and tadalafil for patients with erectile dysfunction: a retrospective study.

International journal of impotence research·2023

Search research articles

Related Experiment Video

Updated: May 12, 2026

A Treatment Protocol for Achilles Tendinopathy with Extracorporeal Shockwave Therapy

A Treatment Protocol for Achilles Tendinopathy with Extracorporeal Shockwave Therapy

Published on: August 2, 2024

Shockwave treatment of erectile dysfunction.

Ilan Gruenwald¹, Boaz Appel, Noam D Kitrey

¹Neuro-Urology Unit, Rambam Medical Center and Rappaport Faculty of Medicine, Technion, Haifa 34679, Israel.

Therapeutic Advances in Urology

|April 5, 2013

Summary

Low-intensity extracorporeal shock wave therapy (LI-ESWT) offers a new approach to treating erectile dysfunction (ED) by promoting natural erections. This novel therapy stimulates neovascularization, showing significant improvements in erectile function and penile hemodynamics without adverse effects.

Keywords:

erectile dysfunction male impotence shockwaves therapy

More Related Videos

Shock Wave Application to Cell Cultures

Shock Wave Application to Cell Cultures

Published on: April 8, 2014

Related Experiment Videos

Last Updated: May 12, 2026

A Treatment Protocol for Achilles Tendinopathy with Extracorporeal Shockwave Therapy

A Treatment Protocol for Achilles Tendinopathy with Extracorporeal Shockwave Therapy

Published on: August 2, 2024

Shock Wave Application to Cell Cultures

Shock Wave Application to Cell Cultures

Published on: April 8, 2014

Area of Science:

Regenerative Medicine
Urology
Biomedical Engineering

Background:

Erectile dysfunction (ED) is a prevalent condition with limited restorative treatment options.
Current ED treatments are primarily palliative, not addressing the underlying pathophysiology.
Low-intensity extracorporeal shock wave therapy (LI-ESWT) has demonstrated angiogenic properties.

Purpose of the Study:

To evaluate the efficacy of LI-ESWT in restoring erectile function in patients with vasculogenic ED.
To investigate the impact of LI-ESWT on penile hemodynamics and erectile mechanism.
To assess the safety and tolerability of LI-ESWT for ED treatment.

Main Methods:

A double-blind, randomized controlled trial was conducted.
LI-ESWT was applied to the cavernosal tissue of patients with vasculogenic ED.
Penile hemodynamics and erectile function were assessed before and after treatment.

Main Results:

LI-ESWT significantly improved clinical erectile function.
Significant enhancements in penile hemodynamics were observed.
No adverse effects were reported during the study period.

Conclusions:

LI-ESWT shows promise as a restorative treatment for vasculogenic ED.
The therapy promotes neovascularization, leading to improved erectile function.
LI-ESWT may represent a new standard of care for men with ED.