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Updated: May 12, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

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Published on: April 23, 2021

Subclinical thyroid dysfunction and cognitive decline in old age.

Liselotte W Wijsman1, Anton J M de Craen, Stella Trompet

  • 1Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

Plos One
|April 5, 2013
PubMed
Summary
This summary is machine-generated.

Subclinical thyroid dysfunction, including hyperthyroidism and hypothyroidism, did not show a consistent link to cognitive decline in older adults. Further research is needed to confirm these findings on thyroid health and cognition.

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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

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Published on: February 14, 2014

Area of Science:

  • Gerontology
  • Endocrinology
  • Neuroscience

Background:

  • Subclinical thyroid dysfunction is a potential risk factor for cognitive decline in the elderly.
  • Previous research on this association has yielded inconsistent results.
  • The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) investigated this link.

Purpose of the Study:

  • To examine the association between subclinical thyroid dysfunction and cognitive decline in elderly individuals.
  • To determine if subclinical hyperthyroidism or hypothyroidism impacts cognitive performance or decline over time.

Main Methods:

  • A prospective longitudinal study of 5,154 elderly participants (aged 70-82) with vascular disease or risk factors.
  • Exclusion of participants using specific thyroid medications.
  • Measurement of thyroid function (TSH and FT4) at baseline and cognitive performance over a 3-year follow-up using five neuropsychological tests.

Main Results:

  • Subclinical hyperthyroidism and hypothyroidism were identified in 65 and 161 participants, respectively.
  • No consistent association was found between subclinical thyroid dysfunction and altered cognitive performance on individual tests.
  • No association was observed between subclinical thyroid dysfunction and the rate of cognitive decline during the follow-up period.

Conclusions:

  • The study found no consistent evidence that subclinical thyroid dysfunction contributes to cognitive impairment or decline in old age.
  • Current data do not support treating subclinical thyroid dysfunction to prevent cognitive dysfunction in later life.
  • Definitive evidence requires large randomized controlled trials.