Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Scholarly Infrastructure of Complex Benign Gynecology: A Bibliometric Analysis of Publication Patterns, Citation Impact, and Field Maturation from 2015-2025.

Journal of minimally invasive gynecology·2026
Same author

3D Modeling of a Myometrially Embedded Intrauterine Device.

Journal of minimally invasive gynecology·2026
Same author

Academic freedom and meaningful international cooperation are needed to safeguard good health and well-being globally.

Nature medicine·2025
Same author

Glucagon-Like Peptide-1 Receptor Agonists in Gynecologic Surgery.

Obstetrics and gynecology·2025
Same author

Abdominal Compression Syndromes in the Hypermobile Ehlers-Danlos Syndrome.

American journal of medical genetics. Part A·2025
Same author

Navigating Operating Room Resource Shortages: Cost, Sustainability, and Environmental Stewardship.

Journal of the American College of Surgeons·2025
Same journal

Another 10 years of PLOS Computational Biology: A data-driven reflection on trends in genomics research.

PLoS computational biology·2026
Same journal

Mobility data resolution needed to inform predictive models of spatial epidemic spread from mobile phone data.

PLoS computational biology·2026
Same journal

DeepMethylation: A deep learning framework for tissue-specific DNA methylation prediction and functional variant annotation.

PLoS computational biology·2026
Same journal

Redefining and estimating the early-phase reproduction ratio for epidemic outbreaks in spatially structured populations.

PLoS computational biology·2026
Same journal

Optimized phenotype definitions boost GWAS power.

PLoS computational biology·2026
Same journal

Detection, communication, and individual identification with deep audio embeddings: A case study with North Atlantic right whales.

PLoS computational biology·2026
See all related articles

Related Experiment Video

Updated: May 12, 2026

Microfluidic Model to Mimic Initial Event of Neovascularization
10:01

Microfluidic Model to Mimic Initial Event of Neovascularization

Published on: April 10, 2021

Angiogenesis: an adaptive dynamic biological patterning problem.

Timothy W Secomb1, Jonathan P Alberding, Richard Hsu

  • 1Department of Physiology and Arizona Research Laboratories, University of Arizona, Tucson, Arizona, United States of America. secomb@u.arizona.edu

Plos Computational Biology
|April 5, 2013
PubMed
Summary
This summary is machine-generated.

This study reveals how blood vessel networks form efficiently through over-abundant growth and selective pruning. These biological mechanisms ensure functional vascular patterns in tissues, crucial for development and disease.

More Related Videos

Investigating Angiogenesis on a Functional and Molecular Level by Leveraging the Scratch Wound Migration Assay and the Spheroid Sprouting Assay
09:16

Investigating Angiogenesis on a Functional and Molecular Level by Leveraging the Scratch Wound Migration Assay and the Spheroid Sprouting Assay

Published on: May 31, 2024

Kinetic Analysis of Vasculogenesis Quantifies Dynamics of Vasculogenesis and Angiogenesis In Vitro
11:03

Kinetic Analysis of Vasculogenesis Quantifies Dynamics of Vasculogenesis and Angiogenesis In Vitro

Published on: January 31, 2018

Related Experiment Videos

Last Updated: May 12, 2026

Microfluidic Model to Mimic Initial Event of Neovascularization
10:01

Microfluidic Model to Mimic Initial Event of Neovascularization

Published on: April 10, 2021

Investigating Angiogenesis on a Functional and Molecular Level by Leveraging the Scratch Wound Migration Assay and the Spheroid Sprouting Assay
09:16

Investigating Angiogenesis on a Functional and Molecular Level by Leveraging the Scratch Wound Migration Assay and the Spheroid Sprouting Assay

Published on: May 31, 2024

Kinetic Analysis of Vasculogenesis Quantifies Dynamics of Vasculogenesis and Angiogenesis In Vitro
11:03

Kinetic Analysis of Vasculogenesis Quantifies Dynamics of Vasculogenesis and Angiogenesis In Vitro

Published on: January 31, 2018

Area of Science:

  • Developmental biology
  • Systems biology
  • Biophysics

Background:

  • Vascular network formation (angiogenesis) is a complex biological patterning problem.
  • Efficient networks require hierarchical structures for transport and dense meshes for diffusion.
  • Networks must adapt to changing demands without compromising blood flow.

Purpose of the Study:

  • To elucidate the mechanisms underlying the formation of functionally adequate vascular networks.
  • To provide a theoretical framework for understanding vascular patterning in normal and pathological conditions.
  • To predict the impact of anti-angiogenesis therapies.

Main Methods:

  • Theoretical simulations integrating experimental data.
  • Modeling stochastic vessel generation in response to hypoxia-induced growth factors.
  • Analysis of structural adaptation and pruning mechanisms.

Main Results:

  • Over-abundant stochastic vessel generation, coupled with pruning, solves the vascular patterning problem.
  • Identified essential biological mechanisms for efficient vascular network development.
  • Predicted vascular property impairments due to defects in these mechanisms.

Conclusions:

  • Vascular network formation relies on a balance of growth and refinement processes.
  • The findings offer a framework for studying angiogenesis in health and disease.
  • The results can inform the development of targeted angiogenesis therapies.