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Related Concept Videos

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Diversity of Protists I

Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
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Related Experiment Video

Updated: May 12, 2026

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)
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Published on: April 6, 2019

A cell-surface phylome for African trypanosomes.

Andrew P Jackson1, Harriet C Allison, J David Barry

  • 1Pathogen Genomics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, England, United Kingdom. a.p.jackson@liv.ac.uk

Plos Neglected Tropical Diseases
|April 5, 2013
PubMed
Summary

African trypanosome cell surface proteins reveal key differences in host interactions. This study compares Trypanosoma brucei surface genes with related species, uncovering unique adaptations and conserved survival mechanisms.

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Using Fluorescent Proteins to Monitor Glycosome Dynamics in the African Trypanosome
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Published on: August 19, 2014

Area of Science:

  • Parasitology
  • Genomics
  • Molecular Evolution

Background:

  • The cell surface of Trypanosoma brucei is vital for host interactions and disease progression.
  • Previous studies suggested Trypanosoma brucei's cell-surface proteome is largely species-specific compared to other trypanosomatids.
  • Understanding African trypanosome surface architecture is key to deciphering their biology.

Purpose of the Study:

  • To compare cell surface protein-encoding genes across African trypanosome species.
  • To investigate the recent evolutionary dynamics of African trypanosome surface architecture.
  • To identify species-specific innovations and conserved features in cell surface proteins.

Main Methods:

  • Construction of a cell surface phylome (CSP) for African trypanosomes.
  • Phylogenetic analysis of 79 gene families with putative surface functions.
  • Comparative genomics of Trypanosoma brucei, Trypanosoma congolense, and Trypanosoma vivax.

Main Results:

  • Transferrin receptor genes crucial for T. brucei survival are conserved in T. congolense but not T. vivax.
  • An expanded family of insect stage-specific surface glycoproteins was identified, including uncharacterized genes.
  • Most expression site-associated genes (ESAGs) in T. brucei are species-specific and absent in T. congolense and T. vivax.

Conclusions:

  • The cell surface phylome provides a comprehensive view of African trypanosome surface architecture evolution.
  • Significant genomic differences in surface proteins exist between African trypanosome species.
  • This study lays the groundwork for exploring developmental and pathological variations in trypanosome surface structures.