Myeloid sarcoma: current approach and therapeutic options.
Batia Avni1, Maya Koren-Michowitz
1Division of Hematology, Chaim Sheba Medical Center Tel Hashomer, Israel and Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles CA, USA.
Therapeutic Advances in Hematology
|April 5, 2013
Summary
Myeloid sarcoma, a rare extramedullary leukemic tumor, can occur with acute myeloid leukemia. This review summarizes current data on its presentation, features, prognosis, and treatment.
Area of Science:
- Hematology
- Oncology
Background:
- Myeloid sarcoma is a rare extramedullary tumor.
- It can present independently or with acute myeloid leukemia (AML).
- Literature is limited to small studies and case reports.
Purpose of the Study:
- To review and synthesize current data on myeloid sarcoma.
- To cover clinical presentation, morphology, cytogenetics, and molecular features.
- To discuss prognosis and treatment strategies.
Main Methods:
- Comprehensive literature search.
- Retrospective analysis of published data.
- Synthesis of findings on myeloid sarcoma.
Main Results:
- Detailed description of myeloid sarcoma presentation.
- Summary of diagnostic features (morphological, cytogenetic, molecular).
- Overview of prognostic factors and treatment options.
Conclusions:
- Myeloid sarcoma requires multidisciplinary management.
- Further research is needed to improve outcomes.
- Early diagnosis and tailored treatment are crucial.
Related Concept Videos
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...