Related Experiment Video
Updated: May 12, 2026
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
Published on: July 28, 2020
Deregulated systemic IL-10/IL-12 balance in advanced and poor prognosis paediatric soft tissue sarcomas
Ewa Bien1, Malgorzata Krawczyk, Ewa Izycka-Swieszewska
1Department of Paediatrics, Haematology, Oncology and Endocrinology, Medical University of Gdansk, Gdansk, Poland. ewabien1@wp.pl
Context:
The roles of interleukin 10 (IL-10) and IL-12 in regulation of cancer growth and Th1/Th2 immune responses towards cancer are unclear.
Objective:
To establish the prognostic significance of serum IL-10 and IL-12 in paediatric soft tissue sarcomas (STS).
Materials And Methods:
ELISA determinations of cytokines were performed as pre-treatment in 59 children with STS and 30 healthy controls.
Results:
Elevated IL-10 and decreased IL-12 serum levels correlated with advanced disease, poor response to chemotherapy and poor outcome. IL-10 ≥ 9.5 pg/ml, IL-12 ≤ 65 pg/ml and lymph nodes involvement independently predicted poor overall survival (OS) in multivariate Cox analysis.
Conclusion:
Serum IL-10/IL-12 balance determination may facilitate to assess risk groups and prognosis in childhood STS.
