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Updated: May 12, 2026

Quantitation of Endothelial Cell Adhesiveness In Vitro
Published on: June 18, 2015
Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts
E C Oelsner1, T D Pottinger, K M Burkart
1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. eco7@columbia.edu
Context:
Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown.
Objective:
Test associations of endothelial biomarkers with FEV1 using instrumental variables.
Methods:
Among 26 907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets.
Results:
ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29 mL and -34 mL per standard deviation of log-transformed biomarker, p < 0.001), as was endothelin-1 among African-Americans (-22 mL, p = 0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1. The instrumental variable for endothelin-1 was non-informative.
Conclusion:
Although ICAM-1, P-selectin and endothelin-1 were inversely associated with FEV1, associations for ICAM-1 and P-selectin do not appear causal.
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