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Updated: May 12, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Systemic treatments for severe pediatric psoriasis: a practical approach
Ann L Marqueling1, Kelly M Cordoro
1Department of Dermatology, School of Medicine, Stanford University, 700 Welch Road, Suite 301, Stanford, CA 94304, USA.
Dermatologic Clinics
|April 6, 2013
Summary
Severe pediatric psoriasis, though rare, can be disabling. This review covers established systemic treatments and newer biologic agents, detailing their use, effectiveness, and safety for managing childhood psoriasis.
Area of Science:
- Pediatric dermatology
- Immunology
- Pharmacology
Background:
- Severe psoriasis in children is uncommon but significantly impacts quality of life.
- Traditional systemic therapies (phototherapy, acitretin, methotrexate, cyclosporine) have long been used.
- Emerging biologic agents show promise for pediatric psoriasis, building on adult data.
Purpose of the Study:
- To review current systemic treatment options for severe pediatric psoriasis.
- To discuss indications, efficacy, adverse effects, and monitoring of these therapies.
- To provide practical guidance on monotherapy and combination treatment strategies.
Main Methods:
- Literature review of established and novel systemic treatments for pediatric psoriasis.
- Analysis of clinical trial data and expert experience with biologic agents.
- Synthesis of information on treatment guidelines, safety profiles, and monitoring protocols.
Main Results:
- Established systemic treatments remain options for severe pediatric psoriasis.
- Biologic agents demonstrate growing efficacy and safety data in pediatric populations.
- Treatment selection requires careful consideration of individual patient factors and drug profiles.
Conclusions:
- A range of systemic therapies, including biologics, are available for severe pediatric psoriasis.
- Evidence-based guidance is crucial for optimizing treatment outcomes and minimizing risks.
- Further research is needed to fully establish long-term safety and efficacy of newer agents.
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