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Relation between transient or persistent acute kidney injury and long-term mortality in patients with myocardial

Joon Seok Choi1, Young A Kim, Min Jee Kim

  • 1Division of Nephrology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

The American Journal of Cardiology
|April 6, 2013
PubMed

Insights

Acute kidney injury (AKI) after myocardial infarction (MI) increases mortality risk. Even transient kidney injury (KI) in MI patients poses a significant long-term death risk, highlighting the need for close monitoring.

Area of Science:

  • Cardiology
  • Nephrology
  • Clinical Outcomes Research

Background:

  • Limited data exist on acute kidney injury (AKI) impact post-myocardial infarction (MI).
  • The long-term mortality effect of transient kidney injury (KI) after MI is not well-validated.

Purpose of the Study:

  • To investigate the association between AKI during hospitalization and 3-year mortality in myocardial infarction (MI) patients.
  • To differentiate the mortality risk between transient and persistent kidney injury (KI) following MI.

Main Methods:

  • Retrospective analysis of 2,110 patients diagnosed with MI.
  • Classification of AKI patients into transient KI and persistent KI groups based on discharge serum creatinine.
  • Multivariate analysis to identify predictors of AKI and assess 3-year mortality risk.

Main Results:

  • 11% of MI patients developed AKI during hospitalization.
  • Transient KI occurred in 65% of AKI patients, persistent KI in 35%.
  • AKI patients faced increased 3-year mortality (HR 1.71 for transient KI, 2.21 for persistent KI) compared to no AKI.

Conclusions:

  • AKI significantly increases the risk of death in MI survivors.
  • Transient KI, despite apparent renal recovery at discharge, is associated with a substantial long-term mortality risk after MI.

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