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Updated: May 12, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
[A case of tacrolimus plus intensive LCAP therapy combination for refractory ulcerative colitis]
Ayako Matsumoto1, Hiroyuki Yajima, Tomoya Murata
1Department of Gastroenterology, National Hospital Organization Nagasaki Medical Center. matsuayak@yahoo.co.jp
Abstract:
A 30-year-old woman was referred to our hospital with recurrent refractory ulcerative colitis. She also suffered from avascular necrosis of the left femoral head caused by steroid use. We had expected that tacrolimus would contribute to remission, but effects remained insufficient even after 16 days of treatment. Intensive leukocytapheresis (LCAP) therapy was added to tacrolimus therapy, and this combination achieved remission. Tacrolimus plus intensive LCAP combination therapy appears useful in treating refractory ulcerative colitis.
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