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Related Experiment Videos

Functional cerebral imaging by susceptibility-contrast NMR.

J W Belliveau1, B R Rosen, H L Kantor

  • 1Department of Radiology, Massachusetts General Hospital, Boston.

Magnetic Resonance in Medicine
|June 1, 1990
PubMed
Summary
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Dynamic contrast-enhanced NMR imaging measures cerebral physiology in vivo. This technique uses ultrafast imaging and magnetic susceptibility changes to track contrast agent transit and assess brain blood volume in dogs.

Area of Science:

  • Neuroimaging
  • Biophysics
  • Cardiovascular Physiology

Background:

  • Cerebral physiology assessment is crucial for understanding brain function and disease.
  • Dynamic contrast-enhanced (DCE) Magnetic Resonance Imaging (MRI) is a powerful tool for in vivo tissue characterization.
  • Quantifying microvascular changes in the brain non-invasively remains a challenge.

Purpose of the Study:

  • To demonstrate the in vivo measurement of cerebral physiology using dynamic contrast-enhanced Nuclear Magnetic Resonance (NMR).
  • To establish a novel method for assessing brain blood volume based on magnetic susceptibility changes.
  • To investigate the differential response of gray and white matter to microvascular stimuli.

Main Methods:

  • Acquisition of time-resolved images of paramagnetic contrast agent transit in the brain.

Related Experiment Videos

  • Utilized an ultrafast NMR imaging technique for rapid data acquisition.
  • Employed a novel image contrast mechanism based on microscopic changes in tissue magnetic susceptibility.
  • Induced global hypercapnia in dogs to create a controlled microvascular stimulus.

    • Main Results:

    • Established a relationship between susceptibility-induced signal change and brain blood volume.
    • Successfully measured the response of both gray and white matter to the induced hypercapnia.
    • Demonstrated the feasibility of dynamic contrast-enhanced NMR for in vivo cerebral physiology assessment.

    Conclusions:

    • Dynamic contrast-enhanced NMR imaging provides a viable method for in vivo cerebral physiology measurement.
    • The novel susceptibility-based contrast mechanism allows for quantitative assessment of brain blood volume.
    • This technique offers insights into the microvascular behavior of different brain tissues.