Related Experiment Video
Updated: May 12, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Nonpharmacologic treatment and prevention strategies for dementia
1University of California, San Francisco, 4150 Clement Street, Box 181, San Francisco, CA 94121, USA. kristine.yaffe@ucsf.edu
Purpose Of Review:
Epidemiologic studies can provide critical evidence to inform the timing and duration of nonpharmacologic interventions. Although more studies are needed to further determine long-term efficacy, the evidence supporting modifiable risk factors for prevention is compelling, and prevention strategies that incorporate multidomain nonpharmacologic factors may have the most impact.
Recent Findings:
Epidemiologic studies have identified a number of promising nonpharmacologic factors that have the potential to lower the risk of developing dementia.
Summary:
Potential modifiable strategies for dementia prevention include cardiovascular risk factors; lifestyle risk factors such as physical, cognitive, and social activity as well as nutrition, smoking, and alcohol use; and sleep quality. Results of randomized controlled trials for the treatment of cardiovascular risk factors have not been consistent, while interventions that increase physical, cognitive, and social activity have demonstrated protective effects for dementia risk. Trials of single-nutrient dietary supplementation have also been conflicting, but focus on multinutrient supplementation shows promise. Observational data also indicate that sleep quality may be a modifiable risk factor for dementia prevention.
Related Concept Videos
Alzheimer's Disease: Treatment
Dementia
The progression of dementia is generally gradual.
Dementia l: Introduction
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists