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Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
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Published on: January 11, 2020

Mild cognitive impairment.

Oscar L Lopez1

  • 1lopezol@upmc.edu

Continuum (Minneapolis, Minn.)
|April 6, 2013
PubMed
Summary
This summary is machine-generated.

Mild cognitive impairment (MCI) describes cognitive deficits in older adults at high risk for dementia. Understanding MCI

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Area of Science:

  • Neurology
  • Geriatrics
  • Cognitive Science

Background:

  • Mild cognitive impairment (MCI) signifies cognitive deficits in older adults preceding dementia.
  • MCI patients face an elevated risk of developing dementia, particularly Alzheimer's disease (AD).
  • Understanding the transition from MCI to AD is crucial for early intervention.

Purpose of the Study:

  • To review the evolving clinical concept of MCI.
  • To discuss the operationalization of current MCI definitions.
  • To explore biomarkers and treatments for MCI.

Main Methods:

  • Review of clinical criteria for MCI diagnosis.
  • Incorporation of biomarker contributions to diagnosis.
  • Assessment of challenges in bedside MCI diagnosis.

Main Results:

  • MCI is a heterogeneous syndrome, potentially coexisting with other disorders.
  • Recent criteria address diverse clinical presentations and biomarker use.
  • Accurate bedside diagnosis can be challenging due to normal cognitive scale scores.

Conclusions:

  • The article traces the clinical evolution and definitions of MCI.
  • Biomarker development aids in identifying neurodegenerative causes.
  • Proposed treatments for MCI are discussed.