Related Experiment Video
Updated: May 12, 2026
05:12
A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
Published on: November 22, 2024
Understanding and treating vascular cognitive impairment.
Philip B Gorelick1, David Nyenhuis
1Saint Mary’s Health Care, 220 Cherry Street SE, H3037, Grand Rapids, MI 49503, USA. pgorelic@trinity-health.org
Continuum (Minneapolis, Minn.)
|April 6, 2013
Summary
Vascular cognitive impairment (VCI) is a common cause of cognitive decline. Understanding VCI
Area of Science:
- Neurology
- Geriatrics
- Public Health
Background:
- Vascular cognitive impairment (VCI) is a significant contributor to cognitive decline in aging populations.
- An estimated one in three individuals may experience stroke, dementia, or both.
- This review aims to guide clinicians in identifying and managing VCI.
Observation:
- Recent advancements have improved understanding of VCI's clinical, pathological, and related disease aspects.
- Pathological insights include cerebral amyloid angiopathy, microinfarcts, and silent strokes.
- Guidance statements have clarified VCI constructs, including pure and mixed forms.
Findings:
- VCI encompasses a range of cognitive and behavioral dysfunctions.
- Cerebral amyloid angiopathy, microinfarcts, and silent strokes are key pathological features.
- VCI frequently co-occurs with Alzheimer disease.
Implications:
- Effective FDA-approved treatments for VCI are currently unavailable.
- Translating research on stroke and heart disease risk factors into VCI prevention is challenging.
- Shared risk factors for VCI and Alzheimer disease highlight the need for integrated prevention strategies.
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