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Updated: May 12, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
Macrocyclic spermidine alkaloids from Androya decaryi L. Perrier
Anne-Cécile Le Lamer1, Nehal Ibrahim, Frédéric Manjary
1Université de Toulouse, UMR 152 UPS-IRD (Pharmacochimie et Pharmacologie pour le Développement-PHARMA DEV), F-31062 Toulouse Cedex 9, France. anne-cecile.le.lamer@univ-tlse3.fr
Researchers isolated five spermidine alkaloids from Androya decaryi leaves. These compounds, including three new ones, showed no significant in vitro antiplasmodial activity against malaria parasites.
Area of Science:
- Natural Products Chemistry
- Medicinal Chemistry
- Pharmacognosy
Background:
- Androya decaryi is a plant species with potential for novel bioactive compound discovery.
- Spermidine alkaloids represent a class of natural products with diverse biological activities.
Purpose of the Study:
- To isolate and characterize new compounds from Androya decaryi leaves.
- To evaluate the in vitro antiplasmodial activity of isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation via Nuclear Magnetic Resonance (NMR) and mass spectrometry.
- X-Ray diffraction analysis for structural confirmation.
Main Results:
- Three new spermidine alkaloids and two known compounds were successfully isolated.
- The structures of all five compounds were fully elucidated.
- None of the isolated compounds exhibited significant in vitro antiplasmodial activity.
Conclusions:
- Androya decaryi leaves contain novel spermidine alkaloids.
- The isolated compounds are not effective against Plasmodium falciparum in vitro.
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