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Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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Evolution of New Traits in Microbes01:24

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Updated: May 12, 2026

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
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Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli

Published on: August 18, 2023

Rewriting evolution--"been there, done that".

David Penny1

  • 1Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand. d.penny@massey.ac.nz

Genome Biology and Evolution
|April 6, 2013
PubMed
Summary
This summary is machine-generated.

A science journalist

Keywords:
phylogeny errorsplacental mammalsrates of evolution

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Published on: May 29, 2008

Area of Science:

  • Evolutionary biology
  • Mammalian phylogenetics

Background:

  • Phylogenetic trees illustrate evolutionary relationships.
  • Accurate rooting of phylogenetic trees is crucial for understanding evolutionary history.

Purpose of the Study:

  • To identify and correct errors in a published phylogeny of placental mammals.
  • To address a common misconception regarding evolutionary rates in myomorph rodents.

Main Methods:

  • Analysis of a published phylogenetic tree of placental mammals.
  • Comparison with established knowledge of rodent evolution and evolutionary rates.

Main Results:

  • The unrooted tree topology was likely correct.
  • The placement of the root was erroneous, stemming from a known artifact of accelerated evolution in myomorph rodents.

Conclusions:

  • Published phylogenies require rigorous vetting, even when presented in high-impact journals.
  • Misinterpretation of evolutionary rates can lead to incorrect phylogenetic rooting.