Related Experiment Video
Updated: May 12, 2026
05:42
A Repetitive Concussive Head Injury Model in Mice
Published on: October 12, 2016
Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers
Steven T DeKosky1, Kaj Blennow, Milos D Ikonomovic
1Office of the Dean and Department of Neurology, University of Virginia School of Medicine, P. O. Box 800793, Charlottesville, VA 22908, USA. dekosky@virginia.edu
Nature Reviews. Neurology
|April 6, 2013
Summary
Traumatic brain injury (TBI) can lead to chronic traumatic encephalopathy (CTE), a progressive neurological disorder. This review covers CTE
Area of Science:
- Neuroscience
- Neuropathology
- Sports Medicine
Background:
- Public awareness of traumatic brain injury (TBI) consequences has grown, driven by athletes and veterans.
- Chronic traumatic encephalopathy (CTE) is increasingly recognized as a late outcome of repetitive TBI.
- Repetitive TBI is linked to progressive neurological dysfunction and neuropsychiatric issues like dementia and aggression.
Purpose of the Study:
- To provide an overview of the latest understanding of CTE pathophysiology.
- To identify key challenges in CTE research and clinical practice.
- To discuss the quantification of CTE risk and the development of biomarkers for TBI and CTE.
Main Methods:
- Literature review of recent studies on TBI and CTE.
- Analysis of current understanding of CTE pathophysiology.
- Identification of research and clinical challenges.
Main Results:
- Repetitive TBI is a significant risk factor for CTE.
- CTE presents with diverse neuropsychiatric symptoms.
- Accurate risk quantification and reliable biomarkers for TBI and CTE are lacking.
Conclusions:
- Understanding CTE pathophysiology is crucial for addressing its long-term consequences.
- Further research is needed to overcome challenges in CTE diagnosis and management.
- Development of biomarkers is essential for early detection and intervention of TBI and CTE.
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