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Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
Published on: February 22, 2015
Primary intracranial germ cell tumors
Shagufta Tahir Mufti1, Awatif Jamal
1Department of Anatomic Pathology, Faculty of Medicine, King Abdulaziz University and Hospital, Jeddah, Kingdom of Saudi Arabia.
Asian Journal of Neurosurgery
|April 6, 2013
Summary
Primary intracranial germ cell tumors (ICGCTs) are rare brain tumors. This study found that suprasellar and basal ganglia ICGCTs have a favorable prognosis, while pineal MMGCTs are more aggressive.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- Primary intracranial germ cell tumors (ICGCTs) are rare, often found in the pineal and suprasellar regions.
- Histologic types include germinoma, teratoma, choriocarcinoma, embryonal carcinoma, yolk sac tumor, and malignant mixed germ cell tumors (MMGCTs).
- Accurate diagnosis is crucial for treatment planning, as germinomas respond well to therapy, while MMGCTs have a poorer prognosis.
Purpose of the Study:
- To detail the clinicopathological and immunohistochemical findings of three primary intracranial germ cell tumor cases.
- To contribute to the understanding of ICGCT presentation and behavior.
Main Methods:
- Retrospective review of three ICGCT cases diagnosed between 1995-2011.
- Cases were identified from the Anatomical Pathology Department archives at King Abdul Aziz University Hospital.
- Analysis included clinical, radiological, and pathological characteristics, alongside immunohistochemistry.
Main Results:
- Histological examination revealed two cases of MMGCTs and one case of germinoma.
- The study presents the specific characteristics and immunohistochemical profiles of these three ICGCTs.
- A review of recent literature on ICGCTs was also conducted.
Conclusions:
- ICGCTs are more common in males; however, this study observed low treatment morbidity and no recurrence in survivors after three years.
- Suprasellar and basal ganglia ICGCTs appear to have a favorable prognosis irrespective of histologic type.
- Pineal MMGCTs may exhibit an aggressive clinical course, necessitating tailored treatment strategies.
