Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...

Insulin Formulations: Types and Delivery

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into rapid-acting...

Pre-Procedural Guidelines for Assessing Blood Pressure

Pre-Procedural Guidelines for Assessing Blood Pressure

Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the patient.

Diabetes: Management and Pharmacotherapy

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...

Insulin: Biosynthesis, Chemistry, and Preparation

Insulin: Biosynthesis, Chemistry, and Preparation

The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment primarily uses...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Early Worsening of Diabetic Retinopathy Following Initiation of Hybrid Closed-Loop/Automated Insulin Delivery Systems in Type 1 Diabetes: A Systematic Review and Structured Study-Level Synthesis.

Diabetes, obesity & metabolism·2026

Same author

AutoML-Multiverse: An Instability-Aware Framework for Quantifying Analytic Variability in Alzheimer's Disease Machine-Learning Studies.

medRxiv : the preprint server for health sciences·2026

Same author

Improved glycaemic control in pancreatic diabetes mellitus following conversion from multiple daily insulin injections to continuous subcutaneous insulin infusion.

HPB : the official journal of the International Hepato Pancreato Biliary Association·2025

Same author

Hybrid Closed-Loop Therapy in Adults with Type 1 Diabetes in England: Long-Term Outcomes from a Real-World Observational Study.

Diabetes technology & therapeutics·2025

Same author

Glycaemic control following total pancreatectomy: room for improvement?

HPB : the official journal of the International Hepato Pancreato Biliary Association·2024

Same author

c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells.

Cells·2020

Search research articles

Related Experiment Video

Updated: May 12, 2026

Improving IV Insulin Administration in a Community Hospital

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Identifying patients for insulin pump therapy.

Gill Morrison¹, Philip Weston

¹Royal Liverpool University Hospital Trust.

|April 9, 2013

Summary

This summary is machine-generated.

Type I diabetes patients increasingly use continuous subcutaneous insulin infusion (CSII), or insulin pump therapy, over daily injections. This article explains the fundamental concepts and principles of CSII.

More Related Videos

Optimized Protocol for Generating Functional Pancreatic Insulin-secreting Cells from Human Pluripotent Stem Cells

Optimized Protocol for Generating Functional Pancreatic Insulin-secreting Cells from Human Pluripotent Stem Cells

Published on: February 2, 2024

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)

Published on: March 14, 2019

Related Experiment Videos

Last Updated: May 12, 2026

Improving IV Insulin Administration in a Community Hospital

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Optimized Protocol for Generating Functional Pancreatic Insulin-secreting Cells from Human Pluripotent Stem Cells

Optimized Protocol for Generating Functional Pancreatic Insulin-secreting Cells from Human Pluripotent Stem Cells

Published on: February 2, 2024

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)

Published on: March 14, 2019

Area of Science:

Endocrinology
Metabolic Diseases

Background:

Growing shift in type I diabetes management from multiple daily injections (MDI) to insulin pump therapy.
Increasing patient adoption of continuous subcutaneous insulin infusion (CSII) for improved glycemic control.

Purpose of the Study:

To provide an overview of the concept of continuous subcutaneous insulin infusion (CSII).
To explain the general principles underlying insulin pump therapy.

Main Methods:

Review of current literature and clinical practices regarding CSII.
Conceptual explanation of CSII technology and its application.

Main Results:

CSII offers an alternative delivery method for insulin therapy.
Understanding the core principles is crucial for effective CSII implementation.

Conclusions:

Continuous subcutaneous insulin infusion (CSII) represents a significant advancement in type I diabetes care.
Familiarity with CSII concepts and principles is essential for healthcare providers and patients transitioning to pump therapy.