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Related Experiment Video

Updated: May 12, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

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Published on: July 27, 2022

Chronic radiation enteritis and malnutrition.

Gwilym James Webb1, Rachael Brooke, Aminda Niroshan De Silva

  • 1Department of Gastroenterology, Wycombe Hospital, High Wycombe, UK.

Journal of Digestive Diseases
|April 9, 2013
PubMed
Summary

Radiation enteritis, often seen after pelvic radiotherapy, causes intestinal malabsorption and malnutrition. This review covers its causes, diagnosis, and management, including dietary changes and nutritional support.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Radiology

Background:

  • Radiation enteritis is intestinal damage from radiotherapy for pelvic/abdominal cancers.
  • It presents as acute or chronic forms, often with diarrhea and malabsorption.
  • Malnutrition is a frequent complication of chronic radiation enteritis (CRE).

Purpose of the Study:

  • To review the etiology, prevalence, symptoms, diagnosis, and management of CRE.
  • To discuss CRE with malnutrition, including functional short bowel syndrome.
  • To outline diagnostic work-up and therapeutic strategies for CRE.

Main Methods:

  • Literature review of etiology, prevalence, symptoms, diagnosis, and management of CRE.
  • Inclusion of functional short bowel syndrome as a cause of malnutrition.
  • Discussion of diagnostic tools like serum markers, endoscopy, and imaging.

Main Results:

  • CRE diagnosis involves excluding other conditions like recurrent malignancy.
  • Management strategies encompass dietary changes, medications, nutritional support, and surgery.
  • Associated conditions like vitamin B12 deficiency require specific treatment.

Conclusions:

  • CRE is a significant complication of pelvic radiotherapy, leading to malabsorption and malnutrition.
  • A multidisciplinary approach is essential for diagnosing and managing CRE.
  • Effective management improves patient outcomes and quality of life.