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Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products

Giancarlo Aldini1, Giulio Vistoli, Milan Stefek

  • 1Department of Pharmaceutical Sciences, University of Milan, Milan, Italy.

Free Radical Research
|April 9, 2013
PubMed

Insights

Advanced glycoxidation and lipoxidation end products (AGEs and ALEs) drive diabetic complications. This review explores pharmaceuticals and natural compounds to inhibit their formation and enhance their degradation, offering therapeutic strategies.

Area of Science:

  • Biochemistry
  • Pathology
  • Pharmacology

Background:

  • Advanced glycoxidation end products (AGEs) and lipoxidation end products (ALEs) are implicated in diabetic complications and other diseases.
  • Their accumulation results from metabolic dysregulation and oxidative stress.

Purpose of the Study:

  • To review current strategies for counteracting AGEs and ALEs.
  • To explore therapeutic interventions targeting the formation and degradation of these compounds.

Main Methods:

  • Literature review of pharmaceuticals and natural compounds.
  • Analysis of mechanisms targeting AGE/ALE formation, degradation, and signaling.

Main Results:

  • Identified inhibitors of AGE and ALE formation.
  • Discussed cross-link breakers and enzymatic/proteolytic degradation pathways.
  • Examined the role of the receptor for advanced glycation end products (RAGE) and its blockade.

Conclusions:

  • Pharmaceuticals and natural compounds offer potential for managing AGEs and ALEs.
  • Targeting RAGE and its ligands presents a promising therapeutic avenue.

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