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Related Concept Videos

Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

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Related Experiment Video

Updated: May 12, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
09:44

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Published on: March 5, 2022

Spontaneous ovarian hyperstimulation syndrome: case report, pathophysiological classification and diagnostic

Nikoletta Panagiotopoulou1, Helen Byers, William G Newman

  • 1O&G Department, Burnley General Hospital, East Lancashire Hospitals NHS Trust, Casterton Avenue, Burnley, UK. nicola.pan@yahoo.com

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|April 9, 2013
PubMed
Summary

Spontaneous ovarian hyperstimulation syndrome (OHSS) is rare and occurs without treatment. This study reports a familial case linked to a specific gene mutation, aiding diagnosis and management.

Keywords:
FSH receptorPathophysiological classificationSpontaneous ovarian hyperstimulation syndrome

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Area of Science:

  • Reproductive Endocrinology
  • Genetics
  • Pathophysiology

Background:

  • Spontaneous ovarian hyperstimulation syndrome (OHSS) is a rare but severe condition.
  • It occurs independently of exogenous gonadotropin stimulation.
  • Early diagnosis and management are critical due to potential morbidity and mortality.

Observation:

  • A familial case of spontaneous OHSS in a mother and daughter is presented.
  • Both patients shared a previously identified heterozygous activating mutation in the Follicle-Stimulating Hormone Receptor (FSHR) gene.
  • This suggests a potential genetic predisposition.

Findings:

  • The study links spontaneous OHSS to an activating FSHR gene mutation.
  • A literature review focused on pathogenesis was conducted.
  • A pathophysiological classification system and diagnostic algorithm are proposed.

Implications:

  • The findings may improve the understanding of spontaneous OHSS pathogenesis.
  • The proposed classification and algorithm can aid clinicians in diagnosing and managing this rare condition.
  • Genetic screening may be considered in familial cases.