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A cholecystokinin-metabolizing enzyme in rat intestine
C M Turkelson1, T E Solomon, J Hamilton
1Veterans Administration Medical Center, Kansas City, MO 64128.
Peptides
|March 1, 1990
Abstract:
Acid extracts of rat intestine contain a material which metabolizes cholecystokinin-33 (CCK-33) to CCK-12. Soybean trypsin inhibitor had little effect on CCK metabolism by the intestinal material. The molecular weight of the CCK-metabolizing activity, estimated by gel filtration, was 34,000. These data suggest rat intestine contains a nontrypsin CCK-metabolizing enzyme. Results from gel filtration also suggest that large CCK forms can be artifactually degraded to smaller ones during chromatography.