Related Experiment Video
Updated: May 12, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
[Enigmatic lymphatic diseases involving the lung]
N Khen-Dunlop1, J Amiel, C Delacourt
1Service de chirurgie viscérale pédiatrique, hôpital Necker-Enfants-malades, 149, rue de Sèvres, 75015 Paris, France.
Revue De Pneumologie Clinique
|April 9, 2013
Summary
Genetic mutations cause rare lymphedema syndromes like Milroy syndrome. Further research is needed to understand lymphatic vessel complexity and associated pulmonary symptoms.
Area of Science:
- Genetics
- Developmental Biology
- Lymphatic System Research
Context:
- Lymphedema associated with developmental malformations, including Milroy syndrome, Hennekam syndrome, Noonan syndrome, Gorham-Stout syndrome, and yellow nail syndrome, are rare conditions.
- Genetic mutations underlying these syndromes have been identified and validated in mouse models.
Purpose:
- To explore the genetic basis of rare lymphedema syndromes.
- To investigate the complex relationship between lymphatic vessels and pulmonary symptoms.
Summary:
- Identified genetic mutations in rare lymphedema syndromes and confirmed findings in mouse models.
- Highlighted the intricate nature of lymphatic vessels and their proximity to the venous system.
- Emphasized the need for continued research into the pulmonary manifestations of these conditions.
Impact:
- Advances understanding of rare genetic lymphedema disorders.
- Provides a foundation for future research into lymphatic system development and function.
- Suggests potential avenues for investigating pulmonary complications in related syndromes.
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