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Updated: May 12, 2026
06:35
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Acute pancreatitis caused by bortezomib
Tevfik Solakoglu1, Pinar Akyol, Tekin Guney
1Department of Gastroenterology, Ankara Ataturk Research and Education Hospital, Bilkent Street, 06800 Ankara, Turkey. tfksolak@yahoo.com.tr
Summary
Bortezomib, a proteasome inhibitor for multiple myeloma, rarely causes acute pancreatitis (AP). This case report details a patient diagnosed with bortezomib-induced AP after standard treatment initiation.
Area of Science:
- Oncology
- Gastroenterology
- Pharmacology
Background:
- Drug-induced pancreatitis is a rare but serious adverse event.
- Bortezomib is a proteasome inhibitor widely used in multiple myeloma treatment.
- The association between bortezomib and acute pancreatitis requires further investigation.
Purpose of the Study:
- To report a rare case of acute pancreatitis (AP) potentially induced by bortezomib.
- To highlight the importance of considering bortezomib as an etiological factor in patients with multiple myeloma presenting with AP.
Main Methods:
- Case report of a 67-year-old male patient with multiple myeloma.
- Clinical observation of symptoms consistent with acute pancreatitis following bortezomib administration.
- Exclusion of common etiological factors for pancreatitis.
Main Results:
- The patient developed acute pancreatitis symptoms on the fourth day of bortezomib therapy.
- Other known causes of pancreatitis were ruled out.
- The diagnosis of bortezomib-induced pancreatitis was established.
Conclusions:
- Bortezomib should be considered a potential cause of acute pancreatitis in patients with multiple myeloma.
- Early recognition and management are crucial for patients experiencing adverse events during bortezomib treatment.
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