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Published on: February 27, 2018
Analgesic use in nonhuman primates undergoing neurosurgical procedures
1Department of Comparative Medicine, University of Rochester, Rochester, New York, USA. louis_divincenti@urmc.rochester.edu
Summary
Effective pain management is crucial for animals undergoing major surgery in biomedical research. A multimodal, preemptive approach to postoperative analgesia is the current standard of care, especially for nonhuman primates.
Area of Science:
- Veterinary Medicine
- Neuroscience
- Animal Welfare
Background:
- Pain management in research animals has significantly evolved.
- Current standards emphasize a multimodal, preemptive approach to postoperative analgesia.
- Nonhuman primates require specific considerations for pain management during neurosurgery.
Purpose of the Study:
- To discuss the pathophysiology of pain in the context of animal research.
- To outline a multimodal analgesia strategy for neurosurgical procedures.
- To highlight considerations for pain management in nonhuman primates undergoing neurosurgery.
Main Methods:
- Review of current veterinary pain management principles.
- Discussion of pain pathophysiology relevant to surgical procedures.
- Application of multimodal analgesia concepts to neurosurgery.
Main Results:
- Multimodal, preemptive analgesia is the established standard of care.
- Understanding pain pathophysiology is key to effective management.
- Tailored approaches are necessary for specific procedures and species.
Conclusions:
- Appropriate analgesia is essential for animals undergoing invasive research surgery.
- A multimodal, preemptive strategy optimizes postoperative pain control.
- Special attention to pain management is required for nonhuman primates in neurosurgical research.
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