Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling and Repair

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Fractures: Bone Repair

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Impact of early life stress on the immune response and bone regeneration after fracture.

Bone reports·2026

Same author

Inhibition of AXL receptor tyrosine kinase increases osteoblast function and bone mass.

Bone research·2026

Same author

MULTIDIMENSIONAL SPATIAL MAPPING OF EXTRACELLULAR MATRIX: CARTILAGINOUS-OSSEOUS COMPOSITE FORMATION, TENDON INTEGRATION AND VASCULARIZATION DURING SKELETAL GROWTH AND REPAIR.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026

Same author

Beyond survival: What drives senescence in trauma, shock and sepsis?

Injury·2026

Same author

Impaired bone healing upon neutrophil-specific adrenoreceptor beta 2 knockout in non-osteoporotic and osteoporotic mice.

NPJ Regenerative medicine·2026

Same author

Bioengineered MSC-derived extracellular vesicles in intervertebral disc therapeutics: A systematic review.

Acta biomaterialia·2026

Search research articles

Related Experiment Video

Updated: May 12, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Bone tissue engineering in osteoporosis.

Franz Jakob¹, Regina Ebert, Anita Ignatius

¹Musculoskeletal Center Wuerzburg and the Vascubone Consortium, University of Wuerzburg, Germany. f-jakob.klh@uni-wuerzburg.de

|April 9, 2013

Summary

Osteoporosis causes fragility fractures and impairs bone healing due to aging and genetics. Advances in bone tissue engineering offer future solutions for bone regeneration in aging populations.

More Related Videos

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Related Experiment Videos

Last Updated: May 12, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Area of Science:

Biomaterials Science
Regenerative Medicine
Orthopedics

Background:

Osteoporosis is a polygenetic, environmentally modifiable disease leading to fragility fractures.
Aging and genetic factors in osteoporosis impair bone healing and regeneration.
The increasing global burden of osteoporosis necessitates advanced bone regeneration strategies.

Purpose of the Study:

To review the current state and future prospects of ex vivo bone tissue engineering.
To identify challenges and recent advancements in developing clinical applications for bone regeneration.
To explore the potential of engineered bone constructs for compromised conditions like osteoporosis.

Main Methods:

Review of current literature on bone tissue engineering, biomaterials, and bioreactor technology.
Analysis of challenges in vascularization and construct survival for ex vivo engineered bone.
Exploration of tailoring applications for specific patient deficits.

Main Results:

Ex vivo bone tissue engineering has not yet achieved routine clinical application despite scaffold and growth factor development.
Key challenges include achieving rapid vascularization for construct survival in vivo.
Recent advancements in bone biology, materials science, and bioreactor technology are paving the way for future clinical applications.

Conclusions:

Standard operating procedures for ex vivo bone tissue engineering are anticipated in the near future.
Engineered bone constructs can be tailored for conditions prevalent in osteoporosis and advanced age.
Further development is crucial to overcome technical hurdles and enable widespread clinical use.