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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Allergic Reactions02:06

Allergic Reactions

Overview
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

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Related Experiment Video

Updated: May 12, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Can patients with common variable immunodeficiency have allergic rhinitis?

Rosana C Agondi1, Myrthes T Barros, Cristina M Kokron

  • 1Division of Clinical Immunology and Allergy, University of São Paulo, São Paulo, Brazil. ragondi@gmail.com

American Journal of Rhinology & Allergy
|April 9, 2013
PubMed
Summary

Allergic rhinitis is common in common variable immunodeficiency (CVID) patients, but traditional allergy tests often yield negative results. Further investigation, like nasal provocation, may be needed to diagnose allergic rhinitis in CVID.

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Area of Science:

  • Immunology
  • Allergy and Clinical Immunology
  • Otorhinolaryngology

Background:

  • Rhinosinusitis is prevalent in common variable immunodeficiency (CVID) patients.
  • Allergic rhinitis (AR) symptoms may be masked by frequent respiratory infections in CVID.
  • Diagnosing AR typically involves patient history, symptoms, and specific immunoglobulin E (IgE) detection.

Purpose of the Study:

  • To identify rhinitis of probable allergic origin in patients diagnosed with CVID.
  • To investigate the prevalence and diagnostic challenges of allergic rhinitis in CVID.

Main Methods:

  • Included 72 adult CVID patients categorized by rhinitis history (suggestive of AR, nonallergic, none).
  • Assessed total and specific IgE levels (in vivo and in vitro).

Main Results:

  • Chronic rhinitis observed in 81.9% of CVID patients; 43% had a history suggestive of AR.
  • Rhinitis history correlated with earlier CVID symptom onset and diagnosis.
  • Specific IgE confirmed AR in only 5.6% of patients; total IgE was undetectable in 86.1%.

Conclusions:

  • Chronic rhinitis in CVID patients can be allergic, despite negative specific IgE tests.
  • Traditional allergy testing is often insufficient for diagnosing AR in CVID.
  • Nasal provocation tests are suggested for investigating AR in CVID patients.