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Efficacy and safety of a parenteral amino acid solution containing alanyl-glutamine versus standard solution in

Marie-Chantal Struijs1, Thomas Schaible, Ruurd M van Elburg

  • 1Department of Pediatric Surgery, Erasmus MC-Sophia, Rotterdam, The Netherlands. a.e.c.j.m.struijs@erasmusmc.nl

Clinical Nutrition (Edinburgh, Scotland)
|April 9, 2013
PubMed

Insights

This pilot study found that alanyl-glutamine (GLN-AA) parenteral nutrition is safe and well-tolerated in infants post-surgery. GLN-AA better reflects infant amino acid needs compared to standard infusions.

Area of Science:

  • Pediatric Nutrition
  • Clinical Trials
  • Parenteral Nutrition

Background:

  • Optimal pediatric amino acid (AA) infusion composition is crucial for infant health.
  • Parenteral nutrition requires careful consideration of amino acid profiles, especially in surgical infants.

Purpose of the Study:

  • To evaluate the safety and efficacy of a novel parenteral AA solution containing alanyl-glutamine (GLN-AA).
  • To compare GLN-AA with a Standard-AA solution in infants undergoing surgical interventions.

Main Methods:

  • A randomized, double-blind, multicentre pilot trial was conducted.
  • Infants received either GLN-AA or Standard-AA for 5-10 days.
  • Plasma amino acid profiles, safety, and efficacy parameters were assessed.

Main Results:

  • Plasma AA profiles in infants receiving GLN-AA were closer to normal ranges than those receiving Standard-AA.
  • No significant clinical or statistical differences in adverse events, safety, or efficacy were observed between groups.
  • Infant demographics (gestational age, birth weight) were comparable between treatment groups.

Conclusions:

  • The novel GLN-AA parenteral solution is safe and well-tolerated in infants post-surgery.
  • GLN-AA more accurately reflects the amino acid requirements of infants compared to standard solutions.
  • This first-in-man study supports the use of GLN-AA in pediatric parenteral nutrition.
Abstract

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