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Related Experiment Video

Updated: May 12, 2026

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

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Published on: January 24, 2020

Subjective cognitive decline: self and informant comparisons.

Richard J Caselli1, Kewei Chen2, Dona E C Locke3

  • 1Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|April 9, 2013
PubMed
Summary

Subjective cognitive decline, whether self- or informant-reported, is linked to psychological distress and lower cognitive function in early Alzheimer's disease (AD) detection. Individuals who develop mild cognitive impairment (MCI) often report decline earlier than their informants.

Keywords:
Cognitive agingMild cognitive impairmentPreclinical Alzheimer's diseaseSubjective cognition

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Area of Science:

  • Neuroscience
  • Gerontology
  • Psychology

Background:

  • Distinguishing subjective cognitive decline from emotional factors in early Alzheimer's disease (AD) remains challenging.
  • The utility of self- versus informant-based subjective cognitive assessments in early AD detection is not fully understood.

Purpose of the Study:

  • To investigate whether self- or informant-based subjective cognitive decline is a better indicator of early-stage Alzheimer's disease (AD).
  • To examine the relationship between subjective cognitive decline, psychological distress, and cognitive performance.

Main Methods:

  • The study involved 447 healthy participants from the Arizona apolipoprotein E (APOE) cohort and their informants.
  • Participants completed the Multidimensional Assessment of Neurodegenerative Symptoms (MANS) questionnaire for both self- and informant-based assessments.

Main Results:

  • Decline was reported by 30.6% of individuals and 26.2% of informants.
  • Both self- and informant-reported decliners showed higher psychological distress and slightly lower cognitive scores.
  • Over 6.7 years, 20 participants developed mild cognitive impairment (MCI). Converters were older, more likely APOE ε4 carriers, and self-reported decline earlier than informants.

Conclusions:

  • Subjective cognitive decline, reported by oneself or an informant, correlates with increased psychological distress and diminished cognitive performance.
  • Individuals who later developed MCI tended to self-report cognitive decline significantly earlier than their informants indicated.