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Updated: May 12, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
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Cingulum injury in patients with diffuse axonal injury: a diffusion tensor imaging study.

Sung Ho Jang1, Seong Ho Kim, Oh Ryong Kim

  • 1Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Republic of Korea.

Neuroscience Letters
|April 9, 2013
PubMed
Summary
This summary is machine-generated.

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Diffuse axonal injury (DAI) significantly impacts the superior cingulum, particularly its anterior portion. Diffusion tensor tractography reveals this vulnerability in DAI patients compared to controls.

Area of Science:

  • Neuroscience
  • Neuroimaging
  • Neurology

Background:

  • The cingulum is a crucial neural tract connecting the orbitofrontal cortex and medial temporal lobe.
  • Assessing cingulum integrity is challenging due to its extensive anatomical course.
  • Diffuse axonal injury (DAI) can affect widespread white matter tracts, including the cingulum.

Purpose of the Study:

  • To investigate regional changes within the cingulum in patients with DAI.
  • To identify specific subregions of the cingulum most affected by DAI.
  • To utilize diffusion tensor tractography (DTT) for quantitative assessment of cingulum injury.

Main Methods:

  • Recruited 21 patients with DAI and 21 healthy controls.
  • Divided the cingulum into anterior, superior (further divided into anterior and posterior portions), posterior, and inferior regions.

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Last Updated: May 12, 2026

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  • Measured fractional anisotropy (FA), apparent diffusion coefficient (ADC), and tract number using DTT.

    • Main Results:

    • Patients with DAI showed lower FA values and tract numbers in the anterior superior cingulum compared to controls.
    • Higher ADC values were observed in both anterior and posterior superior cingulum regions in DAI patients.
    • The anterior portion of the superior cingulum exhibited a greater increase in ADC values (8.1%) than the posterior portion (5.5%).

    Conclusions:

    • The superior cingulum is demonstrably injured in patients with DAI.
    • The anterior superior cingulum is more vulnerable to injury in DAI than the posterior superior cingulum.
    • These findings highlight the anterior superior cingulum as a particularly susceptible area in DAI.