Related Experiment Video

Updated: May 12, 2026

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

[Interpretation of the tuberculin test in children with CD4 lymphocyte cell mediated immunity changes]

R Piñeiro Pérez1, M J Cilleruelo Ortega1, M García López-Hortelano1

  • 1Servicio de Pediatría, Hospital Carlos III, Madrid, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|April 9, 2013
PubMed

Insights

Immunosuppression can cause false negative tuberculin skin tests (TST). This study found no link between CD4 cell counts and TST results in immigrant children, suggesting TST reliability is not directly affected by CD4 levels.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Pediatrics

Context:

  • Tuberculin skin test (TST) is crucial for diagnosing tuberculosis (TB).
  • Immunosuppression, indicated by low CD4 cell counts, may lead to false-negative TST results.
  • Assessing TST reliability in immunocompromised pediatric populations is important.

Purpose:

  • To investigate the association between CD4 cell counts and TST results in immigrant children.
  • To determine if CD4 cell counts modify TST outcomes in this specific population.

Summary:

  • A cross-sectional study included 1074 immigrant children (2003-2008).
  • CD4 counts were analyzed in 884 children; 5.3% had counts <25%.
  • No significant differences in TST results were observed between children with normal and pathological CD4 cell counts.

Impact:

  • Findings suggest CD4 cell counts may not directly influence TST results in immigrant children.
  • Further research with larger cohorts and more children with significantly low CD4 counts is recommended.
  • This study contributes to understanding TST accuracy in pediatric populations with varying immune statuses.

Keywords:
CD4 cell countsChildrenImmunosuppressionInmunodeprimidosLinfocitos CD4NiñosPrueba de tuberculinaTuberculin testTuberculosis

More Related Videos

Enzyme-linked Immunospot Assay (ELISPOT): Quantification of Th-1 Cellular Immune Responses Against Microbial Antigens06:13

Enzyme-linked Immunospot Assay (ELISPOT): Quantification of Th-1 Cellular Immune Responses Against Microbial Antigens

Published on: November 23, 2010

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories: