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Related Experiment Videos

Cognitive functioning and symptomatology in chronic schizophrenia.

H E Nelson1, C Pantelis, K Carruthers

  • 1Charing Cross and Westminster Medical School, Academic Unit, Horton Hospital, Epsom, Surrey.

Psychological Medicine
|May 1, 1990
PubMed
Summary

Chronic schizophrenic patients exhibit significant intellectual decline, particularly in cognitive speed, correlating with negative symptoms. This suggests potential subcortical pathology in Type II schizophrenia.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Chronic schizophrenic patients often exhibit cognitive deficits.
  • Intellectual deterioration is a recognized feature, but its relationship with specific symptoms and functioning speed requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between intellectual functioning, cognitive speed, and symptom severity in chronic schizophrenic patients.
  • To explore potential underlying pathologies, specifically subcortical involvement in Type II schizophrenia.

Main Methods:

  • Assessed intelligence levels (IQ) and cognitive/motor speed in chronic schizophrenic patients.
  • Correlated cognitive measures with the severity of positive and negative symptoms.
  • Examined relationships with age and extent of intellectual decline.

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Main Results:

  • Patients displayed low average IQ (80), attributed to intellectual deterioration from below-average pre-morbid functioning.
  • Cognitive speed was more impaired than overall intellectual level or motor speed.
  • Negative symptom severity, but not positive symptoms, correlated significantly with bradyphrenia (cognitive slowing).

Conclusions:

  • Cognitive slowing (bradyphrenia) in chronic schizophrenia is linked to negative symptoms.
  • Findings support the hypothesis of subcortical pathology contributing to cognitive deficits and negative symptoms in Type II schizophrenia.