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Update meta-analysis on MMP-7 -181A>G polymorphism and cancer risk: evidence from 25 studies
Xueling Yang1, Ya Liu, Yufeng Yang
1Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Jilin, China.
Background:
The matrix metalloproteinase (MMP) can degrade various components of the extracellular matrix and its functional genetic polymorphism may be associated with cancer development. The common MMP-7 (-181A>G) genetic polymorphism has been reported to be functional and may contribute to genetic susceptibility to cancers. However, the association between MMP-7 (-181A>G) and cancer risk remains inconclusive.
Methods:
To better understand the role of MMP-7 (-181A>G) polymorphism in global cancer, we conducted this comprehensive meta-analysis encompassing 6392 cases and 7665 controls.
Results:
Overall, the MMP-7 (-181A>G) polymorphism was associated with higher cancer risk. In the stratified analyses, significant associations were found between the MMP-7 (-181A>G) polymorphism and gastric cancer, ESCC and gynecologic cancer. We also observed that the GG genotype might modulate colorectal cancer risk comparing with the AA genotype (OR=1.31[1.02-1.69]). Moreover, a significantly increased cancer risk was found among Asian populations. When stratified by study design, significantly elevated susceptibility to cancer was found among population-based studies.
Conclusions:
These findings suggested that the MMP-7 (-181A>G) genetic polymorphism may contribute to the susceptibility of cancers, especially among Asian population.
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