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Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

Functions of the Lymphatic and Immune System

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
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Introduction to Lymphatic and Immune System

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B Cell Activation and Differentiation

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Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

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Related Experiment Video

Updated: May 12, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

Development and function of group 2 innate lymphoid cells.

Jennifer A Walker¹, Andrew N J McKenzie

¹MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

Current Opinion in Immunology

|April 9, 2013

Summary

Type-2 innate lymphoid cells (ILC2) are key immune responders discovered recently. Advances in understanding ILC2 regulation offer new avenues for studying immune function and developing therapies for conditions like asthma.

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A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

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Published on: March 3, 2023

Area of Science:

Immunology
Cell Biology

Background:

The innate lymphoid cell (ILC) family includes newly discovered type-2 innate lymphoid cells (ILC2).
ILC2s develop from bone marrow lymphoid progenitors, regulated by RORα and Gata3.
These cells produce IL-5, IL-9, and IL-13.

Purpose of the Study:

To summarize recent advances in the molecular regulation of ILC2 development and function.
To highlight the potential for developing new genetic models for ILC2 research.
To explore therapeutic interventions targeting ILC2s.

Main Methods:

Review of current literature on ILC2 development and function.
Analysis of transcriptional regulation by RORα and Gata3.
Discussion of ILC2 involvement in parasitic infections, asthma, and allergy.

Main Results:

ILC2s are crucial in innate immunity against parasitic worms.
ILC2s play a role in the pathogenesis of asthma and allergic diseases.
Understanding ILC2 regulation provides opportunities for novel therapeutic strategies.

Conclusions:

ILC2s are critical immune cells with significant implications for health and disease.
Further research into ILC2 molecular mechanisms can lead to targeted therapies.
New genetic models are essential for advancing ILC2 research and therapeutic development.