Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Effects and Mechanisms of Yangyin Yiqi Huoxue Formula on the Oral Microecology in Sjögren's Syndrome Model Mice].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition·2026
Same author

Mechanism-driven innovative drug development for primary Sjögren's disease: insights from global clinical trial landscapes.

Clinical and experimental rheumatology·2025
Same author

Development and validation of a novel disulfidptosis-related gene signature for prediction of survival and immune microenvironment in osteosarcoma by WGCNA analysis.

Discover oncology·2025
Same author

Hypophysitis Induced by Tislelizumab: A Case Report of Somnolence and Delirium with Elevated Eosinophils.

The American journal of case reports·2025
Same author

Exploring the immunomodulatory mechanism of total glucosides of paeony on Sjögren's syndrome dry eye disease based on the "gut-eye axis" pathway.

International ophthalmology·2025
Same author

Application of imaging mass cytometry for spatially profiling the microenvironment of salivary glands in primary Sjögren's syndrome.

Cell death & disease·2025

Related Experiment Video

Updated: May 12, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Layer-by-layer assembled polyaspartamide nanocapsules for pH-responsive protein delivery.

Xin Gu1, Jingjing Wang, Yanming Wang

  • 1Key Laboratory of Functional Polymer Materials of MOE, Institute of Polymer Chemistry, Nankai University, Tianjin, 300071, PR China.

Colloids and Surfaces. B, Biointerfaces
|April 9, 2013
PubMed
Summary

Biodegradable nanocapsules were created using polyaspartamide derivatives for protein delivery. These novel nanocapsules show pH-dependent release and good biocompatibility, making them promising for drug delivery applications.

More Related Videos

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Related Experiment Videos

Last Updated: May 12, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

  • Materials Science
  • Biotechnology
  • Polymer Chemistry

Background:

  • Developing novel biodegradable drug delivery systems is crucial for improving therapeutic efficacy and patient compliance.
  • Polyaspartamide derivatives offer a promising platform due to their water solubility, biodegradability, and protein-like structure.

Purpose of the Study:

  • To synthesize and characterize biodegradable shell cross-linked nanocapsules using polyaspartamide derivatives.
  • To investigate the encapsulation and pH-dependent release of a model protein (bovine serum albumin, BSA).
  • To evaluate the biocompatibility of the developed nanocapsules for potential therapeutic applications.

Main Methods:

  • Layer-by-layer assembly of PADH and PACA on silica spheres.
  • Hydrazone cross-linking for shell stabilization.
  • Silica core removal to form hollow nanocapsules.
  • Dynamic light scattering and zeta potential for characterization.
  • In vitro protein encapsulation and release studies.
  • Cell viability assays for biocompatibility assessment.

Main Results:

  • Successfully prepared biodegradable nanocapsules with controlled layer-by-layer assembly.
  • Demonstrated efficient encapsulation of bovine serum albumin (BSA).
  • Observed significant pH-dependent BSA release, with higher rates at acidic pH.
  • Confirmed good biocompatibility of the nanocapsules through cell viability studies.

Conclusions:

  • Biodegradable polyaspartamide-based nanocapsules are effectively synthesized using layer-by-layer assembly and hydrazone cross-linking.
  • These nanocapsules exhibit promising pH-responsive protein release characteristics.
  • The demonstrated biocompatibility suggests their potential as a safe and effective delivery system for proteins and other therapeutics.