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High soluble vascular cell adhesion molecule-1 concentrations predict long-term mortality in hemodialysis patients
Jia-Feng Chang1, Shih-Ping Hsu, Mei-Fen Pai
1Division of Nephrology, Department of Internal Medicine, Far Eastern Memorial Hospital, No. 21, Nan-Ya South Road Sec 2, Banciao District, New Taipei City, 220, Taiwan, ROC, cjf6699@yahoo.com.tw.
Insights
Higher levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) in maintenance hemodialysis patients independently predict cardiovascular mortality. This biomarker can help predict patient outcomes.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Biomarkers
Background:
- Soluble vascular cell adhesion molecule-1 (sVCAM-1) is linked to cardiovascular deaths in coronary artery disease patients.
- Understanding cardiovascular mortality risk in maintenance hemodialysis (MHD) patients is critical.
Purpose of the Study:
- To investigate the association between sVCAM-1 levels and cardiovascular mortality in MHD patients.
- To evaluate sVCAM-1 as a potential predictor of mortality in this population.
Main Methods:
- Eighty-three MHD patients were enrolled in a 7-year follow-up study.
- Baseline levels of sVCAM-1, sICAM-1, and sE-selectin were measured.
- Patients were grouped by median sVCAM-1 concentration.
Main Results:
- Higher sVCAM-1 concentrations were associated with increased all-cause mortality (Kaplan-Meier, p=0.002).
- Cox proportional hazards analysis revealed higher sVCAM-1 independently predicts all-cause (p=0.006) and cardiovascular mortality (p=0.046).
Conclusions:
- Elevated sVCAM-1 levels are an independent predictor of all-cause and cardiovascular mortality in MHD patients.
- sVCAM-1 shows potential as a surrogate marker for predicting adverse outcomes in MHD patients.
Purpose:
Soluble vascular cell adhesion molecule-1 (sVCAM-1) has a strong association with cardiovascular deaths in patients with coronary artery disease. The aim of this study is to explore the association between sVCAM-1 and cardiovascular mortality in maintenance hemodialysis (MHD) patients.
Methods:
Eighty-three clinically stable MHD patients (mean age of 59.4 ± 13.7 years) at a single hospital-based dialysis facility were included. sVCAM-1, soluble intercellular adhesion molecule-1 (sICAM-1), and soluble E-selectin (sE-selectin) were determined at study baseline. The study cohort was divided into higher and lower concentration groups by the median value. The all-cause and cardiovascular mortality of this cohort were followed for 7 years.
Results:
The mean concentrations of sVCAM-1, sICAM-1, and sE-selectin were 1,393.08 ± 300.96, 230.16 ± 84.86, and 60.01 ± 42.00 ng/mL, respectively. The higher concentration groups of sVCAM-1 and sICAM-1 had higher all-cause mortality by Kaplan-Meier analysis (p = 0.002 and p = 0.030, respectively). Higher sVCAM-1 concentrations had a higher risk of all-cause and cardiovascular mortality (p = 0.006 p = 0.046, respectively) in Cox proportional hazards model analysis.
Conclusion:
In MHD patients, higher sVCAM-1 concentrations independently predict all-cause and cardiovascular mortality. This biomarker may be used as a valid surrogate marker for predicting outcomes.
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