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Updated: May 12, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
Type 2 innate lymphocytes in allergic airway inflammation
Roel G J Klein Wolterink1, Rudi W Hendriks
1Department of Pulmonary Medicine, Erasmus MC Rotterdam, Room Ee2251, PO Box 2040, NL 3000, CA Rotterdam, The Netherlands. r.kleinwolterink@erasmusmc.nl
Abstract:
CD4(+) T helper-2 (Th2) cells, which produce a unique profile of IL-4, IL-5 and IL-13 pro-inflammatory cytokines, are thought to be central in the orchestration and amplification of allergic asthma. However, a novel non-T/non-B lymphoid cell population, named type 2 innate lymphocytes (ILC2s), that produces high amounts of IL-5 and IL-13 was recently discovered. Unlike Th2 cells, these ILC2s are not antigen-restricted and are activated by epithelial cell-derived cytokines IL-25 and IL-33. In this review, we will focus on recent studies, mainly involving allergen-based mouse models, that have provided evidence for a significant contribution of ILC2 to allergic airway information.
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