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Updated: May 12, 2026
Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Correlation between microdilution, Etest, and disk diffusion methods for antifungal susceptibility testing of
Everardo Albuquerque Menezes1, Antônio Alexandre de Vasconcelos Júnior, Maria Rozzelê Ferreira Ângelo
1Laboratório de Pesquisa em Microbiologia de Leveduras, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federaldo Ceará, Fortaleza, CE, Brasil.
Introduction:
Antifungal susceptibility testing assists in finding the appropriate treatment for fungal infections, which are increasingly common. However, such testing is not very widespread. There are several existing methods, and the correlation between such methods was evaluated in this study.
Methods:
The susceptibility to fluconazole of 35 strains of Candida sp. isolated from blood cultures was evaluated by the following methods: microdilution, Etest, and disk diffusion.
Results:
The correlation between the methods was around 90%.
Conclusions:
The disk diffusion test exhibited a good correlation and can be used in laboratory routines to detect strains of Candida sp. that are resistant to fluconazole.
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