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The effect of instruments for prothrombin time testing on the international normalized ratio
1Servizio di Immunoematologia e Centro Trasfusionale, Ospedale L. Sacco, Milano.
La Ricerca in Clinica E in Laboratorio
|January 1, 1990
Summary
Prothrombin time (PT) testing, measured as the international normalized ratio (INR), monitors anticoagulant therapy. Thromboplastin
Area of Science:
- Clinical diagnostics
- Hematology
- Biomedical engineering
Background:
- Prothrombin time (PT) testing is crucial for monitoring oral anticoagulant therapy.
- Results are typically reported as the international normalized ratio (INR).
- Standardization of PT/INR relies on the international sensitivity index (ISI) of the thromboplastin reagent.
Purpose of the Study:
- To investigate the standardization of prothrombin time (PT) testing.
- To understand the role of the international sensitivity index (ISI) in PT/INR reporting.
- To explore potential influences on ISI values.
Main Methods:
- Analysis of PT testing procedures.
- Evaluation of international sensitivity index (ISI) determination.
- Comparison of calibration instruments for thromboplastins.
Main Results:
- PT results are commonly expressed as INR for anticoagulant therapy monitoring.
- The international sensitivity index (ISI) is essential for calculating INR.
- Calibration instrument variability may affect ISI values, impacting PT standardization.
Conclusions:
- Accurate PT/INR monitoring depends on reliable ISI values.
- Standardization of PT testing requires careful calibration of thromboplastins.
- Instrumental factors in ISI calibration warrant further investigation for improved PT test accuracy.